FEATURED PUBLICATIONS
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Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan-protein interactions Wang L, Sorum AW, Huang B-S, Kern MK, Su G, Pawar N, Huang X, Liu J, Pohl NLB, Hsieh-Wilson LC. Nat Chem. 2023, 15, 1108-1117 Research briefing: "Synthesis of oligosaccharide libraries for systematic explorations of heparan sulfate sequence space," Nat Chem. 2013, 15, 1062-1063 |
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Chondroitin 4-O-sulfation regulates hippocampal perineuronal nets and social memory Huang H, Joffrin A, Zhao Y, Miller GM, Zhang GC, Oka Y, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2023, 120, e2301312120 QnA with Linda: https://www.pnas.org/doi/10.1073/pnas.2307305120 ACS News Release: https://brnw.ch/21wBIa2 ACS Media Briefing Video: brnw.ch/21wBIBe |
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Tools for mammalian glycoscience research [PDF] Griffin ME, Hsieh-Wilson LC. Cell. 2022, 185, 2657-2677 |
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Sulfated glycans engage the Ang–Tie pathway to regulate vascular development [PDF] Griffin ME, Sorum AW, Miller GM, Goddard III WA, Hsieh-Wilson LC. Nat Chem Biol. 2021, 17, 178–186 |
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Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly [PDF] Pawar NJ, Wang L, Higo T, Bhattacharya C, Kancharla PK, Zhang F, Baryal K, Huo C-X, Liu J, Linhardt RJ, Huang X, Hsieh-Wilson LC. Angew Chem Int Ed. 2019, 58, 18577–18583 |
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Directing Neuronal Signaling through Cell-Surface Glycan Engineering [PDF] Pulsipher A, Griffin ME, Stone SE, Brown JM, Hsieh-Wilson LC. J Am Chem Soc. 2014, 136, 6794–6797 |
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Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF] Yi W, Clark PM, Mason DE, Keenan MC, Hill C, Goddard WA III, Peters EC, Driggers EM, Hsieh-Wilson LC. Science. 2012, 337, 975–980 Featured in: Mattaini KR, Vander Heiden MG, "Glycosylation to Adapt to Stress," Science. 2012, 337, 925–926; Borman S, "Glycosylation Linked to Cancer," Chem Eng News. 2012, 90, 9; Goodman C, "A GlcNAc Switch," Nat Chem Biol. 2012, 8, 809; Ray LB, "Metabolic Sensor," Sci Signal. 2012, 5, ec225 |
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A Sulfated Carbohydrate Epitope Inhibits Axon Regeneration After Injury [PDF] Brown JM, Xia, J, BinQuan Z, Cho K-S, Rogers CJ, Gama CI, Rawat M, Tully SE, Uetani N, Mason D, Tremblay ML, Peters EC, Habuchi O, Chen DF, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2012, 109, 4768–4773 |
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Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation [PDF] Rexach JE, Clark PM, Mason DE, Neve RL, Peters EC, Hsieh-Wilson LC. Nat Chem Biol. 2012, 8, 253–261 |
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Neuroactive Chondroitin Sulfate Glycomimetics [PDF] Rawat M, Gama CI, Matson JB, Hsieh-Wilson LC. J Am Chem Soc. 2008, 130, 2959–2961 Featured in: Chem Eng News. 2009, 87, 28 |
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Probing the Dynamics of O-GlcNAc Glycosylation in the Brain using Quantitative Proteomics [PDF] Khidekel N, Ficarro SB, Clark PM, Bryan M, Swaney DL, Rexach JE, Sun YE, Coon JJ, Peters EC, Hsieh-Wilson LC. Nat Chem Biol. 2007, 3, 339–348 Featured in: Wells L, "A QUICk look at O-GlcNAc dynamics," Nat Chem Biol. 2007, 3, 303–304; "Methods: Sugar on the brain," Nature. 2007, 447, 510–511 |
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Sulfation Patterns of Glycosaminoglycans Encode Molecular Recognition and Activity [PDF] Gama CI, Tully SE, Sotogaku N, Clark PM, Rawat M, Vaidehi N, Goddard WA III, Nishi A, Hsieh-Wilson LC. Nat Chem Biol. 2006, 2, 467–473 Featured in: Turnbull JE, "Synthetic sugars enhance the functional glycomics toolkit," Nat Chem Biol. 2006, 2, 449–450; Doerr A, "Carbohydrate chemistry in California," Nat Methods. 2006, 3, 769; Chem Eng News. 2006, 84, 48 |
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A Chemoenzymatic Approach Toward the Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications [PDF] Khidekel N, Arndt S, Lamarre-Vincent N, Lippert A, Poulin-Kerstien KG, Ramakrishnan B, Qasba PK, Hsieh-Wilson LC. J Am Chem Soc. 2003, 125, 16162–16163 |
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ALL PUBLICATIONS
Chemoenzymatic Labeling, Detection and Profiling of Core Fucosylation in Live Cells [PDF]
Zhu Q, Chaubard J-L, Geng D, Shen J, Ban L, Cheung ST, Wei F, Liu Y, Sun H, Calderon A, Dong W, Qin W, Li T, Wen L, Wang PG, Sun S, Yi W, Hsieh-Wilson LC. J Am Chem Soc. 2024, 146, 26408–26415
Recent Advances in the Synthesis of Extensive Libraries of Heparan Sulfate Oligosaccharides for Structure–Activity Relationship Studies [PDF]
Ramadan S, Mayieka M, Pohl NLB, Liu J, Hsieh-Wilson LC, Huang X. Curr Op Chem Biol. 2024, 80, 102455
Functional Glycoproteomics by Integrated Network Assembly and Partitioning
Griffin ME, Thompson JW, Xiao Y, Sweredoski MJ, Aksenfeld RB, Jensen EH, Koldobskaya Y, Schacht AL, Kim TD, Choudhry P, Lomenick B, Garbis SD, Moradian A, Hsieh-Wilson LC. bioRxiv. 2023. Manuscript in review.
Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan-protein interactions
Wang L, Sorum AW, Huang B-S, Kern MK, Su G, Pawar N, Huang X, Liu J, Pohl NLB, Hsieh-Wilson LC. Nat Chem. 2023, 15, 1108-1117
Chondroitin 4-O-sulfation regulates hippocampal perineuronal nets and social memory
Huang H, Joffrin A, Zhao Y, Miller GM, Zhang GC, Oka Y, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2023, 120, e2301312120
Chemical Glycobiology
Joffrin AM, Sorum AW, Hsieh-Wilson LC. In Advanced Chemical Biology: Chemical Dissection and Reprogramming of Biological Systems, 1st ed.; John Wiley & Sons, 2023, pp. 295-327
Synthesis of a Systematic 64 Membered Heparan Sulfate Tetrasaccharide Library
Baryal K, Ramadan S, Su G, Huo C, Zhao Y, Liu J, Hsieh-WIlson LC, Huang X. Angew Chem Int Ed. 2023, 62, e202211985
Tools for Mammalian Glycoscience Research
Griffin ME, Hsieh-Wilson LC. Cell. 2022, 185, 2657-2677
Expedient Synthesis of a Library of Heparan Sulfate-Like "Head to Tail" Linked Multimers for Structure and Activity Relationship Studies
Ramadan S, Su G, Baryal K, Hsieh-Wilson LC, Liu J, Huang X. Org Chem Front. 2022, 9, 2910-2920
Sulfated glycans engage the Ang–Tie pathway to regulate vascular development [PDF]
Griffin ME, Sorum AW, Miller GM, Goddard III WA, Hsieh-Wilson LC. Nat Chem Biol. 2021, 17, 178–186
Photoaffinity Probes for the Identification of Sequence-Specific Glycosaminoglycan-Binding proteins [PDF]
Joffrin AM, Hsieh-Wilson LC. J Am Chem Soc. 2020, 142, 13672–13676
Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly [PDF]
Pawar NJ, Wang L, Higo T, Bhattacharya C, Kancharla PK, Zhang F, Baryal K, Huo C-X, Liu J, Linhardt RJ, Huang X, Hsieh-Wilson LC. Angew Chem Int Ed. 2019, 58, 18577–18583
Long Non-Coding RNA HOTAIR Promotes Invasion of Breast Cancer Cells Through Chondroitin Sulfotransferase CHST15 [PDF]
Liu LC, Wang YL, Lin PL, Zhang X, Cheng WC, Liu SH, Chen CJ, Hung Y, Jan CI, Chang LC, Qi X, Hsieh-Wilson LC, Wang SC. Int J Cancer. 2019, 145, 2475-2487
O-GlcNAcylation of Core Components of the Translation Initiation Machinery Regulates Protein Synthesis [PDF]
Li X, Zhu Q, Shi X, Cheng Y, Li X, Xu H, Duan X, Hsieh-Wilson LC, Chu J, Pelletier J, Ni M, Zheng Z, Li S, Yi W. Proc Natl Acad Sci USA. 2019, 116, 7857–7866
An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation [PDF]
Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W. ACS Chem Biol. 2019, 14, 4–10
Optimization of Chemoenzymatic Mass Tagging by Strain-Promoted Cycloaddition (SPAAC) for the Determination of O-GlcNAc Stoichiometry by Western Blotting [PDF]
Darabedian D, Thompson JW, Chuh KN, Hsieh-Wilson LC, Pratt MR. Biochemistry. 2018, 57, 5769–5774
A Molecular Window into the Brain: Special Issue on Molecules and the Brain [PDF]
Hsieh-Wilson LC. Biochemistry. 2018, 57, 3989–3990
Deciphering the Functions of O-GlcNAc Glycosylation in the Brain: The Role of Site-Specific Quantitative O-GlcNAcomics [PDF]
Thompson JW, Sorum AW, Hsieh-Wilson LC. Biochemistry. 2018, 57, 4010–4018
Specific Glycosaminoglycan chain length and Sulfation Patterns are Required for Cell Uptake of Tau versus a-synuclein and b-Amyloid [PDF]
Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI. J Biol Chem. 2018, 293, 10826–10840
Tau Internalization is Regulated by 6-O-Sulfation on Heparan Sulfate Proteoglycans (HSPGs) [PDF]
Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS. Sci Rep. 2018, 23, 6382
Structure-Function Characterization of Three Human Antibodies Targeting the Vaccinia Virus Adhesion Molecule D8 [PDF]
Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Bitra A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE Jr, Zajonc DM. J Biol Chem. 2018, 293, 390–401
Methods for the Detection, Study, and Dynamic Profiling of O-GlcNAc Glycosylation [PDF]
Thompson JW, Griffin ME, Hsieh-Wilson LC. Methods Enzymol. 2018, 598, 101–135
Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation
Cheung ST, Miller MS, Pacoma R, Roland J, Liu J, Schumacher AM, Hsieh-Wilson LC. ACS Chem Biol. 2017, 12, 3126–3133
Predicting Glycosaminoglycan-Surface Protein Interactions: Implications for Studying Axonal Growth [PDF]
Griffith AR, Rogers CJ, Miller GM, Abrol R, Hsieh-Wilson LC, Goddard WA III. Proc Natl Acad Sci USA. 2017, 114, 13697–13702
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration [PDF]
Wang AC, Jensen EH, Rexach JE, Vinters HV, Hsieh-Wilson LC. Proc Natl Acad Sci. 2016, 113, 15120-15125
Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag [PDF]
Griffin ME, Jensen EH, Mason DE, Jenkins CL, Stone SE, Peters EC, Hsieh-Wilson LC. Mol Biosyst. 2016, 12, 1756-1759
Glycan engineering for cell and developmental biology [PDF]
Griffin ME, Hsieh-Wilson LC. Cell Chem Biol. 2016, 23, 108-121
Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans [PDF]
Miller GM, Hsieh-Wilson LC. Exp Neurol. 2015, 274, 115-125
Long-lived engineering of glycans to direct stem cell fate [PDF]
Pulsipher A, Griffin ME, Stone SE, Hsieh-Wilson LC. Angew Chem Int Ed. 2015, 54, 1466-1470
Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E [PDF]
Matho MH, de Val N, Miller GM, Brown JM, Schlossman A, Meng X, Crotty S, Peters B, Xiang Y, Hsieh-Wilson LC, Ward AB, Zajonc DM. PLoS Pathog. 2014, 10, e1004495
Photoactivatable glycopolymers for the proteome-wide identification of fucose-α(1-2)-galactose binding proteins [PDF]
Wibowo A, Peters EC, Hsieh-Wilson LC. J Am Chem Soc. 2014, 136, 9528–9531
Directing Neuronal Signaling through Cell-Surface Glycan Engineering [PDF]
Pulsipher A, Griffin ME, Stone SE, Brown JM, Hsieh-Wilson LC. J Am Chem Soc. 2014, 136, 6794–6797
Improving Biologic Drugs via Total Chemical Synthesis [PDF]
Hsieh-Wilson LC, Griffin ME. Science. 2013, 342, 1332-1333
Visualization of O-GlcNAc Glycosylation Stoichiometry and Dynamics using Resolvable Poly(ethylene glycol) Mass Tags [PDF]
Clark PM, Rexach JE, Hsieh-Wilson LC. Curr Protocols Chem Biol. 2013, 5, 281-302
Synthetic Probes of Glycosaminoglycan Function [PDF]
Griffin ME, Hsieh-Wilson LC. Curr Op Chem Biol. 2013, 17, 1014-1022
Tailored Glycopolymers as Anticoagulant Heparin Mimetics [PDF]
Oh YI, Sheng G, Chang S-K, Hsieh-Wilson LC. Angew Chem Int Ed. 2013, 52, 11796-11799
Tunable Heparan Sulfate Mimetics for Modulating Chemokine Activity [PDF]
Sheng G, Oh YI, Chang S-K, Hsieh-Wilson LC. J Am Chem Soc. 2013, 135, 10898-10901
Semaphorin 3A Binds to the Perineuronal Nets via Chondroitin Sulfate Type E (CS-E) Motifs in Rodent Brains [PDF]
Dick G, Tan Cl, Alves JN, Ehlert E, Miller GM, Hsieh-Wilson LC, Sugahara K, Oosterhof A, van Kuppevelt TH, Verhaagen J, Fawcett JW, Kwok JCF. J Biol Chem. 2013, 288, 27384-27395
Activation of the Transcriptional Function of the NF-kB Protein c-Rel by O-GlcNAc Glycosylation [PDF]
Ramakrishnan P, Clark PM, Mason DE, Peters EC, Hsieh-Wilson LC, Baltimore D. Sci Signal. 2013, 6, ra75
Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]
Yi W, Clark PM, Mason DE, Keenan MC, Hill C, Goddard WA III, Peters EC, Driggers EM, Hsieh-Wilson LC. Science. 2012, 337, 975–980
Featured in: Mattaini KR, Vander Heiden MG, "Glycosylation to Adapt to Stress," Science. 2012, 337, 925–926; Borman S, "Glycosylation Linked to Cancer," Chem Eng News. 2012, 90, 9; Goodman C, "A GlcNAc Switch," Nat Chem Biol. 2012, 8, 809; Ray LB, "Metabolic Sensor," Sci Signal. 2012, 5, ec225
A Sulfated Carbohydrate Epitope Inhibits Axon Regeneration After Injury [PDF]
Brown JM, Xia, J, BinQuan Z, Cho K-S, Rogers CJ, Gama CI, Rawat M, Tully SE, Uetani N, Mason D, Tremblay ML, Peters EC, Habuchi O, Chen DF, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2012, 109, 4768–4773
Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-Galactose Glycan Biomarkers [PDF]
Chaubard J-L, Krishnamurthy C, Yi W, Smith D, Hsieh-Wilson LC. J Am Chem Soc. 2012, 134, 4489–4492
Microarray method for the rapid detection of glycosaminoglycan-protein interactions
Rogers CJ, Hsieh-Wilson LC. Carbohydrate Microarrays: Methods and Protocols, Methods in Molecular Biology. 2012, 808, 321–336
Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation [PDF]
Rexach JE, Clark PM, Mason DE, Neve RL, Peters EC, Hsieh-Wilson LC. Nat Chem Biol. 2012, 8, 253–261
Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches [PDF]
Rogers CJ, Clark PM, Tully SE, Abrol R, Garcia KC, Goddard WA III, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2011, 108, 9747–9752
Quantification of O-Glycosylation Stoichiometry and Dynamics using Resolvable Mass Tags [PDF]
Rexach JE, Rogers CJ, Yu S-H, Tao J, Sun Y, Hsieh-Wilson LC. Nat Chem Biol. 2010, 6, 645–651
Featured in: Kohler JJ, "A shift for the O-GlcNAc paradigm," Nat Chem Biol. 2010, 6, 634–635
End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans [PDF]
Lee S-G, Brown JM, Rogers CJ, Matson JB, Krishnamurthy C, Rawat M, Hsieh-Wilson LC. Chem Sci. 2010, 1, 322–325
Identification of the Plasticity-Relevant Fucose-α(1-2)-Galactose Proteome from Mouse Olfactory Bulb [PDF]
Murrey HE, Ficarro SB, Krishnamurthy C, Domino SE, Peters EC, Hsieh-Wilson LC. Biochemistry. 2009, 48, 7261–7270
Site-Specific GlcNAcylation of Human Erythrocyte Proteins: Potential Biomarker(s) for Diabetes Mellitus [PDF]
Wang Z, Park K, Comer F, Hsieh-Wilson LC, Saudek CD, Hart GW. Diabetes. 2009, 58, 309–317
Direct In-Gel Fluorescence Detection and Cellular Imaging of O-GlcNAc-Modified Proteins [PDF]
Clark PM, Dweck JF, Mason D, Hart C, Buck SB, Peters EC, Agnew BJ, Hsieh-Wilson LC. J Am Chem Soc. 2008, 130, 11576–11577
The Chemical Neurobiology of Carbohydrates [PDF]
Murrey HE, Hsieh-Wilson LC. Chem Rev. 2008, 108, 1708–1731
Chemical Approaches to Understanding O-GlcNAc Glycosylation in the Brain [PDF]
Rexach JE, Clark PM, Hsieh-Wilson LC. Nat Chem Biol. 2008, 4, 97–106
Neuroactive Chondroitin Sulfate Glycomimetics [PDF]
Rawat M, Gama CI, Matson JB, Hsieh-Wilson LC. J Am Chem Soc. 2008, 130, 2959–2961
Featured in: Chem Eng News 2009, 87, 28
Activation of Phospholipase C Pathways by Synthetic Chondroitin Sulfate-E Tetrasaccharide Promotes the Neurite Outgrowth of Dopaminergic Neurons [PDF]
Sotogaku N, Tully SE, Gama CI, Higashi H, Tanaka M, Hsieh-Wilson LC, Nishi A. J Neurochem. 2007, 103, 749–760
Probing the Dynamics of O-GlcNAc Glycosylation in the Brain using Quantitative Proteomics [PDF]
Khidekel N, Ficarro SB, Clark PM, Bryan M, Swaney DL, Rexach JE, Sun YE, Coon JJ, Peters EC, Hsieh-Wilson LC. Nat Chem Biol. 2007, 3, 339–348
Featured in: Wells L, "A QUICk look at O-GlcNAc dynamics," Nat Chem Biol. 2007, 3, 303–304; "Methods: Sugar on the brain," Nature. 2007, 447, 510–511
Direct Identification of Nonreducing GlcNAc Residues on N-Glycans of Glycoproteins Using a Novel Chemoenzymatic Method [PDF]
Boeggeman E, Ramakrishnan B, Kilgore C, Khidekel N, Hsieh-Wilson LC, Simpson JT, Qasba PK. Bioconjug Chem. 2007, 18, 806–814
Profiling the Sulfation Specificities of Glycosaminoglycan Interactions with Growth Factors and Chemotactic Proteins Using Microarrays [PDF]
Shipp EL, Hsieh-Wilson LC. Chem Biol. 2007, 14, 195–208
Featured in: Schwartz NB, Cortes M, King LA, "Got Sulfate? Luring Axons This Way and That," Chem Biol. 2007, 14, 119–120
A Sweet Synthesis [PDF]
Hsieh-Wilson LC. Nature. 2007, 445, 31–33
Sulfation Patterns of Glycosaminoglycans Encode Molecular Recognition and Activity [PDF]
Gama CI, Tully SE, Sotogaku N, Clark PM, Rawat M, Vaidehi N, Goddard WA III, Nishi A, Hsieh-Wilson LC. Nat Chem Biol. 2006, 2, 467–473
Featured in: Turnbull JE, "Synthetic sugars enhance the functional glycomics toolkit," Nat Chem Biol. 2006, 2, 449–450; Doerr A, "Carbohydrate chemistry in California," Nat Methods. 2006, 3, 769; Chem Eng News. 2006, 84, 48
Discovery of a TNF-α Antagonist Using Chondroitin Sulfate Microarrays [PDF]
Tully SE, Rawat M, Hsieh-Wilson LC. J Am Chem Soc. 2006, 128, 7740–7741
Protein Fucosylation Regulates Synapsin Ia/Ib Expression and Neuronal Morphology in Primary Hippocampal Neurons [PDF]
Murrey H, Gama CI, Kalovidouris SA, Luo W-I, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2006, 103, 21–26
Featured in: "This Week in PNAS," Sci STKE. 2006, 472, 317; Hart GW, "Sweet insights into learning and memory," Nat Chem Biol. 2006, 2, 67
Chemical approaches to deciphering the glycosaminoglycan code [PDF]
Gama CI, Hsieh-Wilson LC. Curr Op Chem Biol. 2005, 9, 609–619
A Role for Fucose α(1-2) Galactose Carbohydrates in Neuronal Growth [PDF]
Kalovidouris S, Gama CI, Hsieh-Wilson LC. J Am Chem Soc. 2005, 127, 1340–1341
Exploring the O-GlcNAc Proteome: Direct Identification of O-GlcNAc-Modified Proteins [PDF]
Khidekel N, Ficarro SB, Peters EC, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2004, 101, 13132–13137
Featured in: Eisenstin M, "Getting a handle on protein farnesylation," Nat Methods. 2004, 1, 5
Tailor-made Glycoproteins [PDF]
Hsieh-Wilson LC. Trends Biotechnol. 2004, 22, 489–491
Parallel Identification of O-GlcNAc-Modified Proteins from Cell Lysates [PDF]
Tai HC, Khidekel N, Ficarro SB, Peters EC, Hsieh-Wilson LC. J Am Chem Soc. 2004, 126, 10500–10501
A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Outgrowth [PDF]
Tully SE, Mabon R, Gama CI, Tsai SL, Liu X, Hsieh-Wilson LC. J Am Chem Soc. 2004, 126, 7736–7737
Featured in: Borman, S. "Chondroitin Bioactivity." Chem Eng News. 2004, 82, 9
A 'Molecular Switchboard' – Covalent Modifications to Proteins and Their Impact on Transcription [PDF]
Khidekel N, Hsieh-Wilson LC. Org Biomol Chem. 2004, 2, 1–7
A Chemoenzymatic Approach Toward the Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications [PDF]
Khidekel N, Arndt S, Lamarre-Vincent N, Lippert A, Poulin-Kerstien KG, Ramakrishnan B, Qasba PK, Hsieh-Wilson LC. J Am Chem Soc. 2003, 125, 16162–16163
Use of Cerny Expoxides for the Accelerated Synthesis of Glycosaminoglycans [PDF]
Arndt SE, Hsieh-Wilson LC. Org Lett. 2003, 5, 4179–4182
Dynamic Glycosylation of the Transcription Factor CREB: A Potential Role in Gene Regulation [PDF]
Lamarre-Vincent N, Hsieh-Wilson LC. J Am Chem Soc. 2003, 125, 6612–6613
Featured in: Chem. Eng. News 2003, 81, 21
Other Selected Publications
Regulation of Spinophilin Ser94 Phosphorylation in Neostriatal Neurons Involves Both DARPP-32-Dependent and Independent Pathways
Uematsu K, Futter M, Hsieh-Wilson LC, Higashi H, Maeda H, Narin AC, Greengard P, Nishi A. J Neurochem. 2005, 95, 1642–1652
Spinophilin is Phosphorylated by Ca2+/Calmodulin-Dependent Protein Kinase II, Resulting in Regulation of Its Binding to F-Actin
Grossman SD, Futter M, Snyder GL, Allen PB, Nairn AC, Greengard P, Hsieh-Wilson LC. J Neurochem. 2004, 90, 317–324
The Actin-Binding Domain of Spinophilin is Necessary and Sufficient for Targeting to Dendritic Spines
Grossman SD, Hsieh-Wilson LC, Allen PB, Nairn AC, Greengard P. Neuro Mol Medicine. 2002, 2, 61–69
Protein Phosphatase 1 Regulation by Inhibitors and Targeting Subunits
Watanabe T, Huang H-B, Horiuchi A, Hsieh-Wilson LC, Allen PB, Shenolikar S, Greengard P, Nairn AC. Proc Natl Acad Sci USA. 2001, 98, 3080–3085
Control of Protein Phosphatase-1 in the Dendrite
Allen PB, Hsieh-Wilson LC, Yan Z, Feng J, Ouimet CC, Greengard P. Biochem Soc Trans. 1999, 27, 543–546
Protein Phosphatase 1 Modulation of Neostriatal AMPA Channels: Regulation by DARPP-32 and Spinophilin
Yan Z, Hsieh-Wilson LC, Feng J, Tomizawa K Allen PB, Fienberg AA, Nairn AC, Greengard P. Nat Neurosci. 1999, 2, 13–17
Characterization of the Neuronal Targeting Protein Spinophilin and Its Interactions with Protein Phosphatase-1
Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P. Biochemistry. 1999, 38, 4365–4373
Antibody Catalysis of Peptidyl-Prolyl cis-trans Isomerization in the Folding of RNase T1
Ma L, Hsieh-Wilson LC, Schultz PG. Proc Natl Acad Sci USA. 1998, 95, 7251–7256
Structural Studies of Catalytic Antibodies
Stevens RC, Hsieh-Wilson LC, Santarsiero BD, Wedemayer GJ, Spiller B, Wang LH, Barnes D, Ulrich HD, Patten PA, Romesberg FE, Schultz PG. Israel J Chem. 1996, 36, 121–132
Insights into Antibody Catalysis: Structure of an Oxygenation Catalyst at 1.9-Å Resolution
Hsieh-Wilson LC, Schultz PG, Stevens RC. Proc Natl Acad Sci USA. 1996, 93, 5363–5367
Lessons from the Immune System: From Catalysis to Materials Science
Hsieh-Wilson LC, Xiang X-D, Schultz PG. Acc Chem Res. 1996, 29, 164–170
An Efficient Antibody-Catalyzed Oxygenation Reaction
Hsieh LC, Stephans JC, Schultz PG. J Am Chem Soc. 1994, 116, 2167–2168
Progress Toward an Antibody Glycosidase
Yu J, Hsieh LC, Kochersperger L, Yonkovich S, Stephans JC, Gallop MA, Schultz PG. Angew Chem Int Ed. 1994, 33, 339–340
Controlling Chemical Reactivity with Antibodies
Hsieh LC, Yonkovich S, Kochersperger L, Schultz PG. Science. 1993, 260, 337–340
Zhu Q, Chaubard J-L, Geng D, Shen J, Ban L, Cheung ST, Wei F, Liu Y, Sun H, Calderon A, Dong W, Qin W, Li T, Wen L, Wang PG, Sun S, Yi W, Hsieh-Wilson LC. J Am Chem Soc. 2024, 146, 26408–26415
Recent Advances in the Synthesis of Extensive Libraries of Heparan Sulfate Oligosaccharides for Structure–Activity Relationship Studies [PDF]
Ramadan S, Mayieka M, Pohl NLB, Liu J, Hsieh-Wilson LC, Huang X. Curr Op Chem Biol. 2024, 80, 102455
Functional Glycoproteomics by Integrated Network Assembly and Partitioning
Griffin ME, Thompson JW, Xiao Y, Sweredoski MJ, Aksenfeld RB, Jensen EH, Koldobskaya Y, Schacht AL, Kim TD, Choudhry P, Lomenick B, Garbis SD, Moradian A, Hsieh-Wilson LC. bioRxiv. 2023. Manuscript in review.
Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan-protein interactions
Wang L, Sorum AW, Huang B-S, Kern MK, Su G, Pawar N, Huang X, Liu J, Pohl NLB, Hsieh-Wilson LC. Nat Chem. 2023, 15, 1108-1117
Chondroitin 4-O-sulfation regulates hippocampal perineuronal nets and social memory
Huang H, Joffrin A, Zhao Y, Miller GM, Zhang GC, Oka Y, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2023, 120, e2301312120
Chemical Glycobiology
Joffrin AM, Sorum AW, Hsieh-Wilson LC. In Advanced Chemical Biology: Chemical Dissection and Reprogramming of Biological Systems, 1st ed.; John Wiley & Sons, 2023, pp. 295-327
Synthesis of a Systematic 64 Membered Heparan Sulfate Tetrasaccharide Library
Baryal K, Ramadan S, Su G, Huo C, Zhao Y, Liu J, Hsieh-WIlson LC, Huang X. Angew Chem Int Ed. 2023, 62, e202211985
Tools for Mammalian Glycoscience Research
Griffin ME, Hsieh-Wilson LC. Cell. 2022, 185, 2657-2677
Expedient Synthesis of a Library of Heparan Sulfate-Like "Head to Tail" Linked Multimers for Structure and Activity Relationship Studies
Ramadan S, Su G, Baryal K, Hsieh-Wilson LC, Liu J, Huang X. Org Chem Front. 2022, 9, 2910-2920
Sulfated glycans engage the Ang–Tie pathway to regulate vascular development [PDF]
Griffin ME, Sorum AW, Miller GM, Goddard III WA, Hsieh-Wilson LC. Nat Chem Biol. 2021, 17, 178–186
Photoaffinity Probes for the Identification of Sequence-Specific Glycosaminoglycan-Binding proteins [PDF]
Joffrin AM, Hsieh-Wilson LC. J Am Chem Soc. 2020, 142, 13672–13676
Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly [PDF]
Pawar NJ, Wang L, Higo T, Bhattacharya C, Kancharla PK, Zhang F, Baryal K, Huo C-X, Liu J, Linhardt RJ, Huang X, Hsieh-Wilson LC. Angew Chem Int Ed. 2019, 58, 18577–18583
Long Non-Coding RNA HOTAIR Promotes Invasion of Breast Cancer Cells Through Chondroitin Sulfotransferase CHST15 [PDF]
Liu LC, Wang YL, Lin PL, Zhang X, Cheng WC, Liu SH, Chen CJ, Hung Y, Jan CI, Chang LC, Qi X, Hsieh-Wilson LC, Wang SC. Int J Cancer. 2019, 145, 2475-2487
O-GlcNAcylation of Core Components of the Translation Initiation Machinery Regulates Protein Synthesis [PDF]
Li X, Zhu Q, Shi X, Cheng Y, Li X, Xu H, Duan X, Hsieh-Wilson LC, Chu J, Pelletier J, Ni M, Zheng Z, Li S, Yi W. Proc Natl Acad Sci USA. 2019, 116, 7857–7866
An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation [PDF]
Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W. ACS Chem Biol. 2019, 14, 4–10
Optimization of Chemoenzymatic Mass Tagging by Strain-Promoted Cycloaddition (SPAAC) for the Determination of O-GlcNAc Stoichiometry by Western Blotting [PDF]
Darabedian D, Thompson JW, Chuh KN, Hsieh-Wilson LC, Pratt MR. Biochemistry. 2018, 57, 5769–5774
A Molecular Window into the Brain: Special Issue on Molecules and the Brain [PDF]
Hsieh-Wilson LC. Biochemistry. 2018, 57, 3989–3990
Deciphering the Functions of O-GlcNAc Glycosylation in the Brain: The Role of Site-Specific Quantitative O-GlcNAcomics [PDF]
Thompson JW, Sorum AW, Hsieh-Wilson LC. Biochemistry. 2018, 57, 4010–4018
Specific Glycosaminoglycan chain length and Sulfation Patterns are Required for Cell Uptake of Tau versus a-synuclein and b-Amyloid [PDF]
Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI. J Biol Chem. 2018, 293, 10826–10840
Tau Internalization is Regulated by 6-O-Sulfation on Heparan Sulfate Proteoglycans (HSPGs) [PDF]
Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS. Sci Rep. 2018, 23, 6382
Structure-Function Characterization of Three Human Antibodies Targeting the Vaccinia Virus Adhesion Molecule D8 [PDF]
Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Bitra A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE Jr, Zajonc DM. J Biol Chem. 2018, 293, 390–401
Methods for the Detection, Study, and Dynamic Profiling of O-GlcNAc Glycosylation [PDF]
Thompson JW, Griffin ME, Hsieh-Wilson LC. Methods Enzymol. 2018, 598, 101–135
Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation
Cheung ST, Miller MS, Pacoma R, Roland J, Liu J, Schumacher AM, Hsieh-Wilson LC. ACS Chem Biol. 2017, 12, 3126–3133
Predicting Glycosaminoglycan-Surface Protein Interactions: Implications for Studying Axonal Growth [PDF]
Griffith AR, Rogers CJ, Miller GM, Abrol R, Hsieh-Wilson LC, Goddard WA III. Proc Natl Acad Sci USA. 2017, 114, 13697–13702
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration [PDF]
Wang AC, Jensen EH, Rexach JE, Vinters HV, Hsieh-Wilson LC. Proc Natl Acad Sci. 2016, 113, 15120-15125
Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag [PDF]
Griffin ME, Jensen EH, Mason DE, Jenkins CL, Stone SE, Peters EC, Hsieh-Wilson LC. Mol Biosyst. 2016, 12, 1756-1759
Glycan engineering for cell and developmental biology [PDF]
Griffin ME, Hsieh-Wilson LC. Cell Chem Biol. 2016, 23, 108-121
Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans [PDF]
Miller GM, Hsieh-Wilson LC. Exp Neurol. 2015, 274, 115-125
Long-lived engineering of glycans to direct stem cell fate [PDF]
Pulsipher A, Griffin ME, Stone SE, Hsieh-Wilson LC. Angew Chem Int Ed. 2015, 54, 1466-1470
Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E [PDF]
Matho MH, de Val N, Miller GM, Brown JM, Schlossman A, Meng X, Crotty S, Peters B, Xiang Y, Hsieh-Wilson LC, Ward AB, Zajonc DM. PLoS Pathog. 2014, 10, e1004495
Photoactivatable glycopolymers for the proteome-wide identification of fucose-α(1-2)-galactose binding proteins [PDF]
Wibowo A, Peters EC, Hsieh-Wilson LC. J Am Chem Soc. 2014, 136, 9528–9531
Directing Neuronal Signaling through Cell-Surface Glycan Engineering [PDF]
Pulsipher A, Griffin ME, Stone SE, Brown JM, Hsieh-Wilson LC. J Am Chem Soc. 2014, 136, 6794–6797
Improving Biologic Drugs via Total Chemical Synthesis [PDF]
Hsieh-Wilson LC, Griffin ME. Science. 2013, 342, 1332-1333
Visualization of O-GlcNAc Glycosylation Stoichiometry and Dynamics using Resolvable Poly(ethylene glycol) Mass Tags [PDF]
Clark PM, Rexach JE, Hsieh-Wilson LC. Curr Protocols Chem Biol. 2013, 5, 281-302
Synthetic Probes of Glycosaminoglycan Function [PDF]
Griffin ME, Hsieh-Wilson LC. Curr Op Chem Biol. 2013, 17, 1014-1022
Tailored Glycopolymers as Anticoagulant Heparin Mimetics [PDF]
Oh YI, Sheng G, Chang S-K, Hsieh-Wilson LC. Angew Chem Int Ed. 2013, 52, 11796-11799
Tunable Heparan Sulfate Mimetics for Modulating Chemokine Activity [PDF]
Sheng G, Oh YI, Chang S-K, Hsieh-Wilson LC. J Am Chem Soc. 2013, 135, 10898-10901
Semaphorin 3A Binds to the Perineuronal Nets via Chondroitin Sulfate Type E (CS-E) Motifs in Rodent Brains [PDF]
Dick G, Tan Cl, Alves JN, Ehlert E, Miller GM, Hsieh-Wilson LC, Sugahara K, Oosterhof A, van Kuppevelt TH, Verhaagen J, Fawcett JW, Kwok JCF. J Biol Chem. 2013, 288, 27384-27395
Activation of the Transcriptional Function of the NF-kB Protein c-Rel by O-GlcNAc Glycosylation [PDF]
Ramakrishnan P, Clark PM, Mason DE, Peters EC, Hsieh-Wilson LC, Baltimore D. Sci Signal. 2013, 6, ra75
Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]
Yi W, Clark PM, Mason DE, Keenan MC, Hill C, Goddard WA III, Peters EC, Driggers EM, Hsieh-Wilson LC. Science. 2012, 337, 975–980
Featured in: Mattaini KR, Vander Heiden MG, "Glycosylation to Adapt to Stress," Science. 2012, 337, 925–926; Borman S, "Glycosylation Linked to Cancer," Chem Eng News. 2012, 90, 9; Goodman C, "A GlcNAc Switch," Nat Chem Biol. 2012, 8, 809; Ray LB, "Metabolic Sensor," Sci Signal. 2012, 5, ec225
A Sulfated Carbohydrate Epitope Inhibits Axon Regeneration After Injury [PDF]
Brown JM, Xia, J, BinQuan Z, Cho K-S, Rogers CJ, Gama CI, Rawat M, Tully SE, Uetani N, Mason D, Tremblay ML, Peters EC, Habuchi O, Chen DF, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2012, 109, 4768–4773
Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-Galactose Glycan Biomarkers [PDF]
Chaubard J-L, Krishnamurthy C, Yi W, Smith D, Hsieh-Wilson LC. J Am Chem Soc. 2012, 134, 4489–4492
Microarray method for the rapid detection of glycosaminoglycan-protein interactions
Rogers CJ, Hsieh-Wilson LC. Carbohydrate Microarrays: Methods and Protocols, Methods in Molecular Biology. 2012, 808, 321–336
Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation [PDF]
Rexach JE, Clark PM, Mason DE, Neve RL, Peters EC, Hsieh-Wilson LC. Nat Chem Biol. 2012, 8, 253–261
Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches [PDF]
Rogers CJ, Clark PM, Tully SE, Abrol R, Garcia KC, Goddard WA III, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2011, 108, 9747–9752
Quantification of O-Glycosylation Stoichiometry and Dynamics using Resolvable Mass Tags [PDF]
Rexach JE, Rogers CJ, Yu S-H, Tao J, Sun Y, Hsieh-Wilson LC. Nat Chem Biol. 2010, 6, 645–651
Featured in: Kohler JJ, "A shift for the O-GlcNAc paradigm," Nat Chem Biol. 2010, 6, 634–635
End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans [PDF]
Lee S-G, Brown JM, Rogers CJ, Matson JB, Krishnamurthy C, Rawat M, Hsieh-Wilson LC. Chem Sci. 2010, 1, 322–325
Identification of the Plasticity-Relevant Fucose-α(1-2)-Galactose Proteome from Mouse Olfactory Bulb [PDF]
Murrey HE, Ficarro SB, Krishnamurthy C, Domino SE, Peters EC, Hsieh-Wilson LC. Biochemistry. 2009, 48, 7261–7270
Site-Specific GlcNAcylation of Human Erythrocyte Proteins: Potential Biomarker(s) for Diabetes Mellitus [PDF]
Wang Z, Park K, Comer F, Hsieh-Wilson LC, Saudek CD, Hart GW. Diabetes. 2009, 58, 309–317
Direct In-Gel Fluorescence Detection and Cellular Imaging of O-GlcNAc-Modified Proteins [PDF]
Clark PM, Dweck JF, Mason D, Hart C, Buck SB, Peters EC, Agnew BJ, Hsieh-Wilson LC. J Am Chem Soc. 2008, 130, 11576–11577
The Chemical Neurobiology of Carbohydrates [PDF]
Murrey HE, Hsieh-Wilson LC. Chem Rev. 2008, 108, 1708–1731
Chemical Approaches to Understanding O-GlcNAc Glycosylation in the Brain [PDF]
Rexach JE, Clark PM, Hsieh-Wilson LC. Nat Chem Biol. 2008, 4, 97–106
Neuroactive Chondroitin Sulfate Glycomimetics [PDF]
Rawat M, Gama CI, Matson JB, Hsieh-Wilson LC. J Am Chem Soc. 2008, 130, 2959–2961
Featured in: Chem Eng News 2009, 87, 28
Activation of Phospholipase C Pathways by Synthetic Chondroitin Sulfate-E Tetrasaccharide Promotes the Neurite Outgrowth of Dopaminergic Neurons [PDF]
Sotogaku N, Tully SE, Gama CI, Higashi H, Tanaka M, Hsieh-Wilson LC, Nishi A. J Neurochem. 2007, 103, 749–760
Probing the Dynamics of O-GlcNAc Glycosylation in the Brain using Quantitative Proteomics [PDF]
Khidekel N, Ficarro SB, Clark PM, Bryan M, Swaney DL, Rexach JE, Sun YE, Coon JJ, Peters EC, Hsieh-Wilson LC. Nat Chem Biol. 2007, 3, 339–348
Featured in: Wells L, "A QUICk look at O-GlcNAc dynamics," Nat Chem Biol. 2007, 3, 303–304; "Methods: Sugar on the brain," Nature. 2007, 447, 510–511
Direct Identification of Nonreducing GlcNAc Residues on N-Glycans of Glycoproteins Using a Novel Chemoenzymatic Method [PDF]
Boeggeman E, Ramakrishnan B, Kilgore C, Khidekel N, Hsieh-Wilson LC, Simpson JT, Qasba PK. Bioconjug Chem. 2007, 18, 806–814
Profiling the Sulfation Specificities of Glycosaminoglycan Interactions with Growth Factors and Chemotactic Proteins Using Microarrays [PDF]
Shipp EL, Hsieh-Wilson LC. Chem Biol. 2007, 14, 195–208
Featured in: Schwartz NB, Cortes M, King LA, "Got Sulfate? Luring Axons This Way and That," Chem Biol. 2007, 14, 119–120
A Sweet Synthesis [PDF]
Hsieh-Wilson LC. Nature. 2007, 445, 31–33
Sulfation Patterns of Glycosaminoglycans Encode Molecular Recognition and Activity [PDF]
Gama CI, Tully SE, Sotogaku N, Clark PM, Rawat M, Vaidehi N, Goddard WA III, Nishi A, Hsieh-Wilson LC. Nat Chem Biol. 2006, 2, 467–473
Featured in: Turnbull JE, "Synthetic sugars enhance the functional glycomics toolkit," Nat Chem Biol. 2006, 2, 449–450; Doerr A, "Carbohydrate chemistry in California," Nat Methods. 2006, 3, 769; Chem Eng News. 2006, 84, 48
Discovery of a TNF-α Antagonist Using Chondroitin Sulfate Microarrays [PDF]
Tully SE, Rawat M, Hsieh-Wilson LC. J Am Chem Soc. 2006, 128, 7740–7741
Protein Fucosylation Regulates Synapsin Ia/Ib Expression and Neuronal Morphology in Primary Hippocampal Neurons [PDF]
Murrey H, Gama CI, Kalovidouris SA, Luo W-I, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2006, 103, 21–26
Featured in: "This Week in PNAS," Sci STKE. 2006, 472, 317; Hart GW, "Sweet insights into learning and memory," Nat Chem Biol. 2006, 2, 67
Chemical approaches to deciphering the glycosaminoglycan code [PDF]
Gama CI, Hsieh-Wilson LC. Curr Op Chem Biol. 2005, 9, 609–619
A Role for Fucose α(1-2) Galactose Carbohydrates in Neuronal Growth [PDF]
Kalovidouris S, Gama CI, Hsieh-Wilson LC. J Am Chem Soc. 2005, 127, 1340–1341
Exploring the O-GlcNAc Proteome: Direct Identification of O-GlcNAc-Modified Proteins [PDF]
Khidekel N, Ficarro SB, Peters EC, Hsieh-Wilson LC. Proc Natl Acad Sci USA. 2004, 101, 13132–13137
Featured in: Eisenstin M, "Getting a handle on protein farnesylation," Nat Methods. 2004, 1, 5
Tailor-made Glycoproteins [PDF]
Hsieh-Wilson LC. Trends Biotechnol. 2004, 22, 489–491
Parallel Identification of O-GlcNAc-Modified Proteins from Cell Lysates [PDF]
Tai HC, Khidekel N, Ficarro SB, Peters EC, Hsieh-Wilson LC. J Am Chem Soc. 2004, 126, 10500–10501
A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Outgrowth [PDF]
Tully SE, Mabon R, Gama CI, Tsai SL, Liu X, Hsieh-Wilson LC. J Am Chem Soc. 2004, 126, 7736–7737
Featured in: Borman, S. "Chondroitin Bioactivity." Chem Eng News. 2004, 82, 9
A 'Molecular Switchboard' – Covalent Modifications to Proteins and Their Impact on Transcription [PDF]
Khidekel N, Hsieh-Wilson LC. Org Biomol Chem. 2004, 2, 1–7
A Chemoenzymatic Approach Toward the Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications [PDF]
Khidekel N, Arndt S, Lamarre-Vincent N, Lippert A, Poulin-Kerstien KG, Ramakrishnan B, Qasba PK, Hsieh-Wilson LC. J Am Chem Soc. 2003, 125, 16162–16163
Use of Cerny Expoxides for the Accelerated Synthesis of Glycosaminoglycans [PDF]
Arndt SE, Hsieh-Wilson LC. Org Lett. 2003, 5, 4179–4182
Dynamic Glycosylation of the Transcription Factor CREB: A Potential Role in Gene Regulation [PDF]
Lamarre-Vincent N, Hsieh-Wilson LC. J Am Chem Soc. 2003, 125, 6612–6613
Featured in: Chem. Eng. News 2003, 81, 21
Other Selected Publications
Regulation of Spinophilin Ser94 Phosphorylation in Neostriatal Neurons Involves Both DARPP-32-Dependent and Independent Pathways
Uematsu K, Futter M, Hsieh-Wilson LC, Higashi H, Maeda H, Narin AC, Greengard P, Nishi A. J Neurochem. 2005, 95, 1642–1652
Spinophilin is Phosphorylated by Ca2+/Calmodulin-Dependent Protein Kinase II, Resulting in Regulation of Its Binding to F-Actin
Grossman SD, Futter M, Snyder GL, Allen PB, Nairn AC, Greengard P, Hsieh-Wilson LC. J Neurochem. 2004, 90, 317–324
The Actin-Binding Domain of Spinophilin is Necessary and Sufficient for Targeting to Dendritic Spines
Grossman SD, Hsieh-Wilson LC, Allen PB, Nairn AC, Greengard P. Neuro Mol Medicine. 2002, 2, 61–69
Protein Phosphatase 1 Regulation by Inhibitors and Targeting Subunits
Watanabe T, Huang H-B, Horiuchi A, Hsieh-Wilson LC, Allen PB, Shenolikar S, Greengard P, Nairn AC. Proc Natl Acad Sci USA. 2001, 98, 3080–3085
Control of Protein Phosphatase-1 in the Dendrite
Allen PB, Hsieh-Wilson LC, Yan Z, Feng J, Ouimet CC, Greengard P. Biochem Soc Trans. 1999, 27, 543–546
Protein Phosphatase 1 Modulation of Neostriatal AMPA Channels: Regulation by DARPP-32 and Spinophilin
Yan Z, Hsieh-Wilson LC, Feng J, Tomizawa K Allen PB, Fienberg AA, Nairn AC, Greengard P. Nat Neurosci. 1999, 2, 13–17
Characterization of the Neuronal Targeting Protein Spinophilin and Its Interactions with Protein Phosphatase-1
Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P. Biochemistry. 1999, 38, 4365–4373
Antibody Catalysis of Peptidyl-Prolyl cis-trans Isomerization in the Folding of RNase T1
Ma L, Hsieh-Wilson LC, Schultz PG. Proc Natl Acad Sci USA. 1998, 95, 7251–7256
Structural Studies of Catalytic Antibodies
Stevens RC, Hsieh-Wilson LC, Santarsiero BD, Wedemayer GJ, Spiller B, Wang LH, Barnes D, Ulrich HD, Patten PA, Romesberg FE, Schultz PG. Israel J Chem. 1996, 36, 121–132
Insights into Antibody Catalysis: Structure of an Oxygenation Catalyst at 1.9-Å Resolution
Hsieh-Wilson LC, Schultz PG, Stevens RC. Proc Natl Acad Sci USA. 1996, 93, 5363–5367
Lessons from the Immune System: From Catalysis to Materials Science
Hsieh-Wilson LC, Xiang X-D, Schultz PG. Acc Chem Res. 1996, 29, 164–170
An Efficient Antibody-Catalyzed Oxygenation Reaction
Hsieh LC, Stephans JC, Schultz PG. J Am Chem Soc. 1994, 116, 2167–2168
Progress Toward an Antibody Glycosidase
Yu J, Hsieh LC, Kochersperger L, Yonkovich S, Stephans JC, Gallop MA, Schultz PG. Angew Chem Int Ed. 1994, 33, 339–340
Controlling Chemical Reactivity with Antibodies
Hsieh LC, Yonkovich S, Kochersperger L, Schultz PG. Science. 1993, 260, 337–340
